cellular house cleaning and a shift away from glucose toward fat burning. Here we have something for everybody. Lounge lizards could reap the benefits of the phytonutrient pattern only effect, while the more restless spirits among us could enhance those effects by dietary and exercise regimens. Either way, organs and tissues other than cardiovascular and skeletal muscle could become larger recipients of resveratrol’s benefits. Numerous daily, weekly and monthly variations of the theme could be envisioned. One plan might be to include one meal a
day to cause chronic fasting default to regenesis and/or with exercise to assist regenesis with glucose nutrient debt and/or a CR mimetic to activate the AMPK life extension loop.
A very interesting rat study of intermittent CR has put the world of CR afficionados on its ear. Using alternate days of ad libitum food supply and total fasting, in rats, results in no long term CR, as the rats make up for fasting by feasting between fast days, while ending up with life extension comparable to CR. This more or less jives with the down regulation of PGC-1alpha to regenesis turn on time frame. In fact, this study is the actual proof of principle, since life extension by CR can’t happen without it. This also jives with our notion that, at least partial neogenesis followed by regenesis, won’t hurt life extension, and you can avoid the misery and downside risks of genuine CR.
An interesting question emerges here. Since regenesis is a CR long term life extension holding pattern, how long is it good for? By this, we mean: Once mitochondria become efficient, how long do they stay efficient before they need restimulated to become efficient again? In other words, how many days of