feast can one ‘get away with’ before each day of fasting? If regenesis is good for a week, then a one day a week fast is a small price to pay. Not only that, if 18 hours of fasting works as well as 24, then all one would needs do is miss breakfast once a week. Can this be supplemented with a low or high dose resveratrol regimen that would accentuate the effect?
We need experiments and we need them earlier rather than later. But rats live five or more years, and rats are not people, (as opposed, oft-times, to the other way around). Over the counter metformin is over a decade away, if ever, and rapamycin is too dangerous to become street legal in any time, dimension or reality. Metformin, when used with growth hormone to mechanistically force the system to toggle back and forth between neogenesis and regenesis could ultimately turn out to be the greatest anti-aging plus rejuvenation achievement of all time. This could truly cause
cells to behave more like they do in the juvenile stage. The timing, dosage and testing required in such a scenario would be critical. This is playing with some real big mojo, here, and it would be illegal without a prescription under a doctor’s care. Only people, at least in their early middle years, say past thirty, could participate in such a program, safely.
Fortunately, at present, we have resveratrol, which is freely obtainable and we know enough about CR and mitochondrial neogenesis and regenesis, to get answers, fast, and in humans instead of rats. Human volunteers and tissue biopsies that measure CR via AMPK activity and mitochondrial biogenic state from krebs cycle enzymes vs. cytochrome content, can allow us to follow the system status through time. The system is well enough