we think the mechanism is. Diabetic lung cancer victims live longer with metformin, but the researchers do not make the CR connection. Dietary resveratrol with exercise increases mitochondrial muscle volume more than exercise alone or resveratrol alone and slows ventricular hypertrophy. What is the connection? Mitochondrial biogenesis measurements sometimes show one thing and sometimes show another, and scientists are befuddled because they don’t know the difference between neogenesis and regenesis. Arguments erupt in kingpin pharmaceutical companies over whether resveratrol is a CR mimetic, or not, because researchers haven’t separated CR meta-mimicry from CR mimicry. Everywhere we look, we see examples like this, where specialists understand one or two trees so well and the forest so poorly that the conclusions become almost strange, contradictory and surreal. Many scientists, in the fields we have visited, wouldn’t be so surprised or perplexed, if they only had a single unifying global hypothesis to make their results coherent. We have such a theory, and all these conundrums make sense to us. Prudent applications of such a theory can have breathtaking impacts upon the nation’s medical bill and the aggregate number of years added to human life; in the first case, measured in the trillions of dollars, and in the second case, measured in the billions of years. This is big stuff … really big stuff.
Gregory S. Bambeck Ph.D. e-mail: gregorybambeck@yahoo.com