defined, by now that the meanings of these assays point to causation rather than correlation. A wide array of experiments could be rapidly conducted, and could pinpoint which timings, conditions and regimens are optimal, whether there are any down sides and what other items might be included. Ideally, we may find a CR mimetic dose schedule of resveratrol, a better mimetic or a mixture of synergistic components that require no life style changes outside of normal prudent health practices … except for that magic pill, of course.
AFTERWORD
About a week after we completed our first draft of the practical applications section, we read in the newspaper that exercise physiologists had discovered that ‘carbohydrate loading,’ health-wise, was far inferior to fasting prior to and during a work-out. The ‘carb loading’ thing may work if you’re training for the Tour de France, but it isn’t for the average Joe. Fasting caused non-oxygen sugar burning to shift over to oxygen fat burning and inefficient white muscle to shift into efficient red muscle, simultaneous with advantageous cardiovascular effects, weight loss and
reduction in diabetes-causing insulin resistance. Quizzically, they hypothesized that hunger induced adrenaline was instituting the changes. Perhaps there is a better hypothesis, and you can probably guess what we think it is. Several months after we published our first paper on cancer metabolism, which describes a thirty year old hypothesis, researchers announced a ‘newly discovered’ cancer growth stopping hyperglycolysis blocking concept therapy that ‘reawakened’ (their words) mitochondrial regenesis (our words). Then they fumble around for the concept of a mechanism. We are pretty firm on what