to intracellular metabolic shifts over time. In other words, even though sugar powered the creation of our lives from inception to birth, it will eventually kill us even if we don’t eat it. This is ‘natural’ aging, and the data clearly shows that unnatural or supra-natural efforts must be made to obtain the unnatural or supra-natural state called life extension beyond the natural or normally expected limit. Face it, caloric restriction (CR) is draconian and is only natural in the sense that, in nature, food sometimes runs out. No organism exists that will ‘naturally’ CR itself in the presence of adequate food. Mega doses of anti-oxidants or a hundred bottles of wine worth of resveratrol a day is, decidedly, unnatural. In a related vein, amino acid restriction, in the form of a dietary reduction of methionine, seems to act in synergy as a CR mimetic. However, such a dietary regimen seems far too complex, restricted and unnatural to be practical in a preliminary review such as this one. We will leave such things for future consideration in an expanded applications document, later.
That being said, such things have been found to stand the test of time. For instance, the Chinese have been drinking a high resveratrol Japanese knotweed root extract, called itadoli tea, for millennia with claimed beneficial results and no known ill effects save for some occasional intestinal discomfort, found to be mostly due to emodin, a co extract, which incidentally, is not found in modern concoctions. The remainder of this brief discussion is mostly devoted to some unnaturally ‘natural’ stuff that folks might do without having to live a supplement menagerie supported life in near anorexia with its attendant impediments to muscularity, wound